Abstract Search

8.2. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress

C Steenblock , MF Rubin de Celis , LF Delgadillo Silva , V Pawolski , A Brennand , M Werdermann , I Berger , A Santambrogio , M Peitzsch , CL Andoniadou , AV Schally , SR Bornstein

To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(51): 1299713002.Humans are constantly challenged by multiple stressors, to which the bodys response and adaptation are essential. The adrenal gland plays a major role in the response to both physiological challenges and stress. Maintenance of the adrenal is partly accomplished by proliferation and differentiat...

0 shares

ey0018.1-9 | Genetics | ESPEYB18

1.9. Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development

EJ Lodge , P Xekouki , TS Silva , C Kochi , CA Longui , FR Faucz , A Santambrogio , JL Mills , N Pankratz , J Lane , D Sosnowska , T Hodgson , AL Patist , P Francis-West , F Helmbacher , C Stratakis , CL Andoniadou

JCI Insight. 2020 Oct 27;5(23):e134310. doi: 10.1172/jci.insight.134310. PMID: 33108146.Lodge et al. screened 28 patients with pituitary stalk interruption syndrome (PSIS) for mutations in the FAT/DCHS (FAT atypical cadherin/ Dachsous cadherin-related) family of protocadherins. FAT2 and DCHS2 putative damaging variants were found in 6/28 patients with ectopic ...

0 shares

ey0019.1-4 | Basic Science and Stem Cells | ESPEYB19

1.4. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

P Russell John , Lim Xinhong , Santambrogio Alice , Yianni Val , Kemkem Yasmine , Wang Bruce , Fish Matthew , Haston Scott , Grabek Anae¨lle , Hallang Shirleen , J Lodge Emily , L Patist Amanda , Schedl Andreas , Mollard Patrice , Nusse Roel , Andoniadou Cynthia L

Elife. 2021 Jan. 10:e59142. doi: https://doi.org/10.7554/eLife.59142.Brief Summary: The authors studied genetic mice models to show that pituitary stem cells can secrete WNT ligands to their committed progeny and promote their expansion.The anterior pituitary contains a population of Sox2 expressing stem cells (Sox2+ PSCs), which self-renew and give rise to lineage...

0 shares

ESPE Yearbook of Paediatric Endocrinology

8.2. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress

1.9. Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development

1.4. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

BiosciAbstracts